874-63-5

Basic information

• Product Name: 3,5-Dimethylanisole
• Synonyms: 1,3-DIMETHYL-5-METHOXYBENZENE;3,5-DIMETHYLANISOLE;5-METHOXY-M-XYLENE;SPECS AC-509/25002099;1-Methoxy-3,5-dimethylbenzene;Anisole, 3,5-dimethyl;Benzene, 1-methoxy-3,5-dimethyl-;3,5-DIMETHYLANISOLE, 99+%
• CAS NO: 874-63-5
• Molecular Formula: C₉H₁₂O
• Molecular Weight: 136.19
• EINECS: 212-865-3
• Product Categories: Aromatic Ethers;Anisoles, Alkyloxy Compounds & Phenylacetates;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 874-63-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 193 °C(lit.)
• Flash Point: 150 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 0.963 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.616mmHg at 25°C
• Refractive Index: n20/D 1.512(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2040905
• CAS DataBase Reference: 3,5-Dimethylanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethylanisole(874-63-5)
• EPA Substance Registry System: 3,5-Dimethylanisole(874-63-5)

Safety Data

• Safety Statements: 24/25
• RIDADR: 3271
• WGK Germany: 3
• Hazardous Substances Data: 874-63-5(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to light yellow liquid

InChI:InChI=1/C9H12O/c1-7-4-8(2)6-9(5-7)10-3/h4-6H,1-3H3

Upstream product

• 2845-83-2 4-methoxypent-3-en-2-one 
• 67-56-1 methanol 
• 1123-09-7 3,5-dimethyl-2-cyclohexen-1-one 
• 21009-92-7 enolate de dimethyl-2',4' methoxy-6' acetophenone 
• 74-88-4 methyl iodide 
• 616-38-6 carbonic acid dimethyl ester 
• 108-68-9 3,5-Dimethylphenol 
• 2320-30-1 3,5-dimethylcyclohexanone 
• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 
• 6981-15-3 4-chloro-3,5-dimethylanisole 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 108-67-8 1,3,5-trimethyl-benzene 
• 100667-93-4 ethyl 2,6-dimethyl-4-methoxycyclohexa-1,3-dienecarboxylate 
• 60-29-7 diethyl ether 

Downstream Products

• 85785-30-4 (4-methoxy-2,6-dimethyl-phenyl)-(4-nitro-phenyl)-diazene 
• 5384-14-5 1-(2-methoxy-4,6-dimethyl-phenyl)-propan-1-one 
• 51926-66-0 2-methoxy-4,6-dimethoxybenzyl alcohol 
• 19447-00-8 4-methoxy-2,6-dimethylbenzylaldehyde 
• 19111-77-4 2,6-dimethyl-4-methoxybenzonitrile 
• 22921-84-2 2,4,6-Trichlor-3,5-dimethyl-anisol 
• 527-61-7 2,6-dimethyl-1,4-benzoquinone 
• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 
• 83385-81-3 1,3-dibromo-6-methoxy-2,4-dimethylbenzene 
• 53847-10-2 2,6-dimethyl-4-methoxynitrosobenzene 
• 701-69-9 4-methoxy-2,6-dimethylbenzenethiol 
• 16196-14-8 bis-(4-methoxy-2,6-dimethyl-phenyl)-amine 
• 90643-86-0 2,6-dimethyl-4-methoxybenzenesulfonamide 
• 38319-83-4 1-(2-hydroxy-4,6-dimethylphenyl)-2-phenylethan-1-one 

Relevant articles and documents

A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination

A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.

A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives

3,3-Disubstituted oxindoles were divergently synthesized by diastereoselective transformations including nucleophilic addition, alkylation, and cycloaddition using common, axially chiral N-aryl oxindoles. Notably, high diastereoselectivities (up to >95:5) were observed with ortho-monosubstituted N-aryl oxindoles to give various oxindole scaffolds, and facile removal of the p-(benzyloxy)aryl moiety in axially twisted amides was achieved by a mild, two-step sequence.

Deuterated Benzopyran Compounds and Application Thereof

The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.