Technology Process of 7-benzyloxy-6-benzyloxycarbonylamino-3,5-dihydroxy-heptanoic acid tert-butyl ester
There total 5 articles about 7-benzyloxy-6-benzyloxycarbonylamino-3,5-dihydroxy-heptanoic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
acetic acid; tetramethylammonium triacetoxyborohydride;
In
acetonitrile;
at -35 ℃;
for 62h;
DOI:10.1055/s-2006-941602
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: MgCl2
2.1: NaBH4 / diethyl ether
3.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
3.2: 75 percent / hexane; tetrahydrofuran / 1.5 h / 0 - 20 °C
4.1: 81 percent / Me4N(OAc)3BH; AcOH / acetonitrile / 62 h / -35 °C
With
sodium tetrahydroborate; n-butyllithium; acetic acid; diisopropylamine; magnesium chloride; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; diethyl ether; hexane; acetonitrile;
4.2: Heathcock-Claisen condensation / 5.1: Evans reduction;
DOI:10.1055/s-2006-941602
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: MgCl2
2.1: NaBH4 / diethyl ether
3.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
3.2: 75 percent / hexane; tetrahydrofuran / 1.5 h / 0 - 20 °C
4.1: 81 percent / Me4N(OAc)3BH; AcOH / acetonitrile / 62 h / -35 °C
With
sodium tetrahydroborate; n-butyllithium; acetic acid; diisopropylamine; magnesium chloride; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; diethyl ether; hexane; acetonitrile;
3.2: Heathcock-Claisen condensation / 4.1: Evans reduction;
DOI:10.1055/s-2006-941602
