(5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene

Base Information

Chemical Name:(5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene
CAS No.:909109-04-2
Molecular Formula:C₂₂H₂₄N₂O₁₂
Molecular Weight:508.439
Hs Code.:

Synonyms:(5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene

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Chemical Property of (5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene

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Technology Process of (5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene

There total 3 articles about (5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 74310-44-4
3,4,5,7-tetra-O-acetyl-2,6-anhydro-1-deoxy-D-gluco-hept-1-enitol

: 1011-84-3
4-nitrobenzohydroximoyl chloride

: 909109-04-2
(5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.tetlet.2006.06.058

Reference yield:

: 105539-34-2
3,4,5,7-tetrakis-O-(triethylsilyl)-2,6-anhydro-1-deoxy-D-glucono-hept-1-enitol

: 909109-04-2
(5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: TBAF / tetrahydrofuran / 4 h / 20 °C

1.2: 97 percent / pyridine / 24 h / 20 °C

2.1: 94 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2006.06.058

Reference yield:

: 1129-37-9,174848-02-3,20707-69-1
4-nitrobenzaldehyde oxime

: 909109-04-2
(5R,7R,8R,9S,10R)-8,9,10-tris(acetoxy)-7-[(acetoxy)methyl]-3-(4-nitrophenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With N-chloro-succinimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.12.004