(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

Base Information

Chemical Name:(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde
CAS No.:208938-33-4
Molecular Formula:C₁₆H₂₆O₂Si
Molecular Weight:278.467
Hs Code.:

Synonyms:(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

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Chemical Property of (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

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Technology Process of (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

There total 3 articles about (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 208938-29-8
tert-Butyl-dimethyl-((2R,3S)-3-methyl-3-phenyl-oxiranylmethoxy)-silane

: 208938-33-4
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

Guidance literature:: With methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); In dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4039(98)00576-0

Reference yield:

: tert-Butyl-dimethyl-((E)-3-phenyl-but-2-enyloxy)-silane

: 208938-33-4
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / AD-mix-α, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C

2: 1.) MsCl, Et₃N, 2.) K₂CO₃ / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH

3: 97 percent / methylaluminium bis(4-bromo-2,6-di-tert-butyl-phenoxide (MABR) / CH₂Cl₂ / -78 °C

With AD-mix-α; methanesulfonamide; potassium carbonate; methanesulfonyl chloride; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)00576-0

Reference yield:

: 208938-26-5
(2S,3S)-1-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-butane-2,3-diol

: 208938-33-4
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) MsCl, Et₃N, 2.) K₂CO₃ / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH

2: 97 percent / methylaluminium bis(4-bromo-2,6-di-tert-butyl-phenoxide (MABR) / CH₂Cl₂ / -78 °C

With potassium carbonate; methanesulfonyl chloride; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00576-0