3-FLUORO-4-PHENOXYANILINE

Base Information

• Chemical Name: 3-FLUORO-4-PHENOXYANILINE
• CAS No.: 39177-22-5
• Molecular Formula: C₁₂H₁₀FNO
• Molecular Weight: 203.216
• Hs Code.: 2921420090
• Mol file: 39177-22-5.mol

Synonyms:3-fluoro-4-phenoxy-phenylamine

Chemical Property of 3-FLUORO-4-PHENOXYANILINE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-Fluoro-4-phenoxyaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 3-FLUORO-4-PHENOXYANILINE

There total 6 articles about 3-FLUORO-4-PHENOXYANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

2-fluoro-4-nitro-1-phenoxy-benzene (189181-21-3) → 3-fluoro-4-phenoxy-phenylamine (39177-22-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h; under 760.051 Torr;

Reference yield:

phenol (108-95-2,27073-41-2) → 3-fluoro-4-phenoxy-phenylamine (39177-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 5 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) + phenol (108-95-2,27073-41-2) → 3-fluoro-4-phenoxy-phenylamine (39177-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.83 h / 140 °C / Microwave irradiation

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 2068.65 Torr

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethyl acetate;

upstream raw materials:

2-fluoro-4-nitro-1-phenoxy-benzene

phenol

3,4-difluoronitrobenzene

1-bromo-2-fluoro-4-nitrobenzene

Refernces

• 1、 -. "Indole compound as well as preparation method, pharmaceutical composition and application thereof". Paragraph 1153; 1159-1161. . Retrieved 2019/12/02.
• 2、 -. "INHIBITORS OF BRUTON'S TYROSINE KINASE". Page/Page column 59; 60; 63; 67; 68. . Retrieved 2015/06/25.