4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride

Base Information

Chemical Name:4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride
CAS No.:1146157-84-7
Molecular Formula:C₁₇H₁₈FN₃O₃*ClH
Molecular Weight:367.808
Hs Code.:

Synonyms:4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride

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Chemical Property of 4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride

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Technology Process of 4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride

There total 1 articles about 4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146157-82-5
3-{6-[3-fluoro-4-(2-hydroxyethylcarbamoyl)phenyl]pyridin-3-yloxy}-azetidine-1-carboxylic acid tert-butyl ester

: 1146157-84-7
4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 16h;

Reference yield:

: 1146157-84-7
4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride

: 55805-22-6
4-(1,1-difluoroethyl)benzaldehyde

: 1146157-06-3
4-(5-{1-[4-(1,1-difluoroethyl)benzyl]azetidin-3-yloxy}-pyridin-2-yl)-2-fluoro-N-(2-hydroxyethyl)benzamide

Guidance literature:: 4-[5-(azetidin-3-yloxy)pyridin-2-yl]-2-fluoro-N-(2-hydroxyethyl)benzamide hydrochloride; 4-(1,1-difluoroethyl)benzaldehyde; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 16h;

With water; sodium hydrogencarbonate; In dichloromethane; 1,2-dichloro-ethane;