2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester

Base Information

• Chemical Name: 2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester
• CAS No.: 1491169-10-8
• Molecular Formula: C₁₆H₁₇FN₂O₂
• Molecular Weight: 288.322
• Mol file: 1491169-10-8.mol

Synonyms:2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester

Chemical Property of 2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester

There total 3 articles about 2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-cyano-3-(2-fluorophenyl)but-2-enoic acid ethyl ester (1491169-09-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester (1491169-10-8)

Guidance literature:

at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

2'-Fluoroacetophenone (445-27-2) → 2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester (1491169-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; ammonium acetate / toluene / 10 h / Reflux; Dean-Stark

2: 2 h / 0 - 20 °C

With ammonium acetate; acetic acid; In toluene;

DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → 2-cyano-5-(dimethylamino)-3-(2-fluorophenyl)penta-2,4-dienoic acid ethyl ester (1491169-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; ammonium acetate / toluene / 10 h / Reflux; Dean-Stark

2: 2 h / 0 - 20 °C

With ammonium acetate; acetic acid; In toluene;

DOI:10.1016/j.ejmech.2013.07.050

upstream raw materials:

2'-Fluoroacetophenone

ethyl 2-cyanoacetate

2-cyano-3-(2-fluorophenyl)but-2-enoic acid ethyl ester

N,N-dimethyl-formamide dimethyl acetal