Technology Process of (2R,3S)-4-(4-bromobenzyloxy)-2-methylbutane-1,3-diol
There total 4 articles about (2R,3S)-4-(4-bromobenzyloxy)-2-methylbutane-1,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methylmagnesium bromide; (2S,3R)-4-(p-bromobenzyloxy)-2,3-epoxybutan-1-ol;
With
copper(l) iodide;
In
tetrahydrofuran; diethyl ether;
at -40 ℃;
for 4h;
With
sodium periodate;
In
tetrahydrofuran; water;
for 12h;
Further stages.;
DOI:10.1021/jo020537q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 72 percent / t-butyl hydroperoxide; titanium(IV) isopropoxide; L-diisopropyl tartrate / molecular sieves 4 Angstroem / CH2Cl2; toluene / 20 h / -35 °C
2.1: cuprous iodide / diethyl ether; tetrahydrofuran / 4 h / -40 °C
2.2: 62 percent / sodium periodate / tetrahydrofuran; H2O / 12 h
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; L-(+)-diisopropyl tartrate;
4 A molecular sieve;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
1.1: Sharpless epoxidation;
DOI:10.1021/jo020537q
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 88 percent / sodium hydride; tetrabutylammonium iodide / tetrahydrofuran / 15 h / 0 - 20 °C
2.1: 72 percent / t-butyl hydroperoxide; titanium(IV) isopropoxide; L-diisopropyl tartrate / molecular sieves 4 Angstroem / CH2Cl2; toluene / 20 h / -35 °C
3.1: cuprous iodide / diethyl ether; tetrahydrofuran / 4 h / -40 °C
3.2: 62 percent / sodium periodate / tetrahydrofuran; H2O / 12 h
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; L-(+)-diisopropyl tartrate; tetra-(n-butyl)ammonium iodide; sodium hydride;
4 A molecular sieve;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
2.1: Sharpless epoxidation;
DOI:10.1021/jo020537q
