(1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride

Base Information

Chemical Name:(1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride
CAS No.:1430746-27-2
Molecular Formula:C₂₃H₃₁N₃O₄*ClH
Molecular Weight:449.978
Hs Code.:

Synonyms:(1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride

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Chemical Property of (1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride

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Technology Process of (1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride

There total 5 articles about (1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430745-40-6
(1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430746-27-2
(1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

Reference yield:

: 4-((1R,4r)-4-((1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile dihydrochloride

: 1430746-27-2
(1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane; toluene / 0.5 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 89284-61-7
4-chloro-nicotinonitrile

: 1430746-27-2
(1R,3s,5S)-isopropyl 3-((1r,4R)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

3: triethylamine / dichloromethane; toluene / 0.5 h / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;