N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa

Base Information

Chemical Name:N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa
CAS No.:72634-68-5
Molecular Formula:C₃₅H₃₁NO₈S
Molecular Weight:625.699
Hs Code.:

Synonyms:N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa

Chemical Property:

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Technology Process of N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa

There total 3 articles about N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 98-88-4
benzoyl chloride

: 72634-67-4
N-(3-mercapto-2-methylpropanoyl)-L-α-methyldopa

: 72634-68-5
N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa

Guidance literature:: With sodium hydroxide; In diethyl ether; water; 1.) ice bath temperature, 1h, 2.) room temperature, 1h;
DOI:10.1248/cpb.29.1203

Reference yield:

: 555-30-6,555-29-3,88620-56-8
methyldopa

: 72634-68-5
N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, isobutyl chloroformate, 2.) sodium borate, triethylamine / 1.) THF, -10 deg C, 10 min, 2.) THF, water, room temperature, 1h

2: 80 percent / aqueous ammonia / methanol / 1.5 h / Ambient temperature

3: 86 percent / 1N sodium hydroxide / H₂O; diethyl ether / 1.) ice bath temperature, 1h, 2.) room temperature, 1h

With sodium borate; ammonium hydroxide; sodium hydroxide; triethylamine; isobutyl chloroformate; In methanol; diethyl ether; water;
DOI:10.1248/cpb.29.1203

Reference yield:

: 79559-48-1,79559-49-2
N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-L-α-methyldopa

: 72634-68-5
N-(S-benzoyl-3-mercapto-2-methylpropanoyl)-O,O'-dibenzoyl-L-α-methyldopa

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aqueous ammonia / methanol / 1.5 h / Ambient temperature

2: 86 percent / 1N sodium hydroxide / H₂O; diethyl ether / 1.) ice bath temperature, 1h, 2.) room temperature, 1h

With ammonium hydroxide; sodium hydroxide; In methanol; diethyl ether; water;
DOI:10.1248/cpb.29.1203