ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate

Base Information

• Chemical Name: ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate
• CAS No.: 219922-26-6
• Molecular Formula: C₃₁H₄₄N₂O₄
• Molecular Weight: 508.701
• Mol file: 219922-26-6.mol

Synonyms:ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate

Chemical Property of ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate

There total 11 articles about ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid (99469-99-5) + 1-(2-piperidino-phenyl)-heptylamine (219921-62-7) → ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate (219922-26-6)

Guidance literature:

With tetrachloromethane; triethylamine; triphenylphosphine; In acetonitrile; for 15h; Ambient temperature;

DOI:10.1021/jm9810349

Reference yield:

2-(piperidin-1-yl)benzonitrile (72752-52-4) → ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate (219922-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; toluene / 3 h / Heating

2: NaBH₄ / methanol / 2 h / 15 °C

3: 80 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With tetrachloromethane; sodium tetrahydroborate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; toluene; acetonitrile;

DOI:10.1021/jm9810349

Reference yield:

2-hydroxy-p-toluic acid (50-85-1) → ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate (219922-26-6)

Guidance literature:

Multi-step reaction with 6 steps

1: K₂CO₃ / diethyl ether / 30 h / 150 °C

2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl₄

3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH₂Cl₂ / 43 h / 20 °C

4: HCl / Heating

5: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C

6: 80 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With hydrogenchloride; tetrachloromethane; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); benzyltri(n-butyl)ammonium chloride; potassium carbonate; triethylamine; triphenylphosphine; In tetrachloromethane; diethyl ether; ethanol; dichloromethane; acetonitrile;

DOI:10.1021/jm9810349

upstream raw materials:

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

1-(2-piperidino-phenyl)-heptylamine

piperidine

2-(piperidin-1-yl)benzonitrile