((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol

Base Information

Chemical Name:((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol
CAS No.:865308-27-6
Molecular Formula:C₁₉H₃₀O₄Si
Molecular Weight:350.53
Hs Code.:

Synonyms:((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol

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Technology Process of ((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol

There total 13 articles about ((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 865308-23-2
((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methyl acetate

: 865308-27-6
((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 0.5h;
DOI:10.1039/b507401k

Reference yield:

: 1027938-82-4
cumyldimethylsilyl trifluoromethanesulfonate

: 865308-27-6
((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / pyridine / toluene / 2 h / 0 °C

2: 98 percent / aq. HCl / tetrahydrofuran / 1.5 h / 0 °C

3: 91 percent / PdCl₂ / dimethylformamide / 0 °C

4: 100 percent / K₂CO₃ / methanol / 0.5 h / 20 °C

With pyridine; hydrogenchloride; potassium carbonate; palladium dichloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b507401k

Reference yield:

: methyl (4E)-2-benzyloxy-2-(2-[t-butyldimethylsiloxy]ethyl)-3-hydroxyhex-4-enoate

: 865308-27-6
((1R,5S,7R)-7-(cumyldimethylsiloxy)-5-methyl-4,8-dioxabicyclo[3.2.1]octyl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / pyridine / 0 °C

2: 92 percent / DIBAL / CH₂Cl₂ / -18 °C

3: 45 percent / lithium di-tert-butylbiphenylide / tetrahydrofuran / -78 °C

4: 98 percent / pyridine; DMAP / 20 °C

5: aq. HCl / tetrahydrofuran / 20 °C

6: 91 percent / PdCl₂ / dimethylformamide / 0 °C

7: 100 percent / K₂CO₃ / methanol / 0.5 h / 20 °C

With pyridine; hydrogenchloride; dmap; lithium di-tert-butylbiphenylide; diisobutylaluminium hydride; potassium carbonate; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b507401k