4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole

Base Information

Chemical Name:4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole
CAS No.:1448032-45-8
Molecular Formula:C₁₅H₁₉Br₂N₃O₃Si
Molecular Weight:477.228
Hs Code.:

Synonyms:4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole

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Technology Process of 4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole

There total 2 articles about 4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24067-17-2
4-nitrophenylboronic acid

: 159590-01-9
2,4,5-tribromo-1-<<2-(trimethylsilyl)ethoxy>methyl>-1H-imidazole

: 1448032-45-8
4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; water; toluene; at 120 ℃; for 5h; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0032-1316906

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1448032-45-8
4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; toluene; water / 5 h / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; water; toluene; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1055/s-0032-1316906

Reference yield:

: 1448032-45-8
4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-(4-nitrophenyl)-1H-imidazole

: 97717-40-3
2-(4-nitrophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; toluene; water / 5 h / 120 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; methanol; water; toluene; 1: |Suzuki-Miyaura Coupling;
DOI:10.1055/s-0032-1316906