Pentanamide,2-(acetylamino)-4-methyl-, (2S)-

Base Information

• Chemical Name: Pentanamide,2-(acetylamino)-4-methyl-, (2S)-
• CAS No.: 28529-34-2
• Molecular Formula: C8H16N2O2
• Molecular Weight: 172.22
• Hs Code.: 2924199090
• Mol file: 28529-34-2.mol

Synonyms:Valeramide, 2-acetamido-4-methyl-, L- (8CI);N-Acetyl-L-leucinamide;N-Acetyl-L-leucine amide;Pentanamide,2-(acetylamino)-4-methyl-, (S)-;(S)-2-(Acetylamino)-4-methylpentanamide;

Chemical Property of Pentanamide,2-(acetylamino)-4-methyl-, (2S)-

Chemical Property:

• Vapor Pressure: 2.16E-06mmHg at 25°C
• Refractive Index: 1.462
• Boiling Point: 393.2 °C at 760 mmHg
• Flash Point: 191.6 °C
• PSA: 72.19000
• Density: 1.024 g/cm³
• LogP: 1.11370
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

Acetyl-L-leucine amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentanamide,2-(acetylamino)-4-methyl-, (2S)-

There total 8 articles about Pentanamide,2-(acetylamino)-4-methyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

N-Ac-Leu (1188-21-2) → N-acetyl-L-leucine amide (28529-34-2)

Guidance literature:

N-Ac-Leu; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With ammonium hydroxide; In tetrahydrofuran; for 0.5h;

DOI:10.1021/acs.joc.8b03224

Reference yield:

(S)-4-isobutyl-2-methyloxazol-5(4H)-one (13649-95-1) → N-acetyl-L-leucine amide (28529-34-2)

Guidance literature:

With ammonia; In toluene; at 80 ℃; for 0.5h;

DOI:10.1021/ja00364a041

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → N-acetyl-L-leucine amide (28529-34-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / 4N NaOH / 1 h / 0 °C

2: 1.) isobutylchloroformate, N-ethylmorpholine, 2.) ammonia / 1.) -15 deg C, 5 min, 2.) -15 deg C, 30 min

3: 1.) 5percent Pd/C / 1.) 80percent glacial acetic acid, overnight, 2.) pyridine

With N-ethylmorpholine;; sodium hydroxide; palladium on activated charcoal; ammonia; isobutyl chloroformate;

DOI:10.1007/BF00648899

upstream raw materials:

N-benzyloxycarbonyl-L-leucinamide

acetic anhydride

(S)-4-isobutyl-2-methyloxazol-5(4H)-one

N-acetyl-L-leucine methyl ester

Downstream raw materials:

2-methyl-4-isobutyl-5-benzamidooxazole