rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1558682-36-2
Molecular Formula:C₂₆H₂₈F₆N₂O₄
Molecular Weight:546.51
Hs Code.:

Synonyms:rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

There total 6 articles about rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 886503-47-5
2-methoxy-4,6-bis-trifluoromethyl-benzoyl chloride

: 1558682-35-1
rac-3-amino-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

: 1558682-36-2
rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ml500005m

Reference yield:

: 622-42-4
1-nitro-1-phenylmethane

: 1558682-36-2
rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Amberlyst A-21 / 1,4-dioxane / 20 °C

2: ammonium acetate / water; ethanol / 26 h / Inert atmosphere; Reflux

3: hydrogen / tetrahydrofuran; water / 7 h / 0 °C / 760.05 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

5: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2: |Mannich Aminomethylation;
DOI:10.1021/ml500005m

Reference yield:

: 22049-87-2
rac-4-nitro-4-phenyl-butyric acid methyl ester

: 1558682-36-2
rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium acetate / water; ethanol / 26 h / Inert atmosphere; Reflux

2: hydrogen / tetrahydrofuran; water / 7 h / 0 °C / 760.05 Torr

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

4: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; 1: |Mannich Aminomethylation;
DOI:10.1021/ml500005m