rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Base Information

Chemical Name:rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide
CAS No.:1236303-76-6
Molecular Formula:C₂₃H₂₄F₆N₂O₂
Molecular Weight:474.446
Hs Code.:

Synonyms:rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

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Technology Process of rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

There total 8 articles about rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1236303-73-3
rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

: 75-03-6
ethyl iodide

: 1236303-76-6
rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 622-42-4
1-nitro-1-phenylmethane

: 1236303-76-6
rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: Amberlyst A-21 / 1,4-dioxane / 20 °C

2: ammonium acetate / water; ethanol / 26 h / Inert atmosphere; Reflux

3: hydrogen / tetrahydrofuran; water / 7 h / 0 °C / 760.05 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

5: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2: |Mannich Aminomethylation;
DOI:10.1021/ml500005m

Reference yield:

: 22049-87-2
rac-4-nitro-4-phenyl-butyric acid methyl ester

: 1236303-76-6
rac-N-(1-ethyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium acetate / water; ethanol / 26 h / Inert atmosphere; Reflux

2: hydrogen / tetrahydrofuran; water / 7 h / 0 °C / 760.05 Torr

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

4: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

6: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1: |Mannich Aminomethylation;
DOI:10.1021/ml500005m