4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester

Base Information

• Chemical Name: 4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester
• CAS No.: 201402-18-8
• Molecular Formula: C₁₉H₂₉NO₅
• Molecular Weight: 351.443

Synonyms:4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester

Chemical Property of 4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester

Chemical Property:

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Technology Process of 4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester

There total 2 articles about 4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) + Tyr(tBu) (16874-12-7,87553-74-0) → 4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (201402-18-8)

Guidance literature:

With potassium tert-butylate; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

Reference yield:

methanolic hydrogen chloride + (2S)-2-(1-Adamantyl-methyloxycarbonylamino)-3-(4-(3-guanidinocarbonyl-propyloxy)phenyl)propionic Acid (202259-31-2) + 2,2'-oxybis(2-methyl-propane) (6163-66-2) → 4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (201402-18-8)

Guidance literature:

palladium hydroxide/carbon; In methanol;

Reference yield:

5-bromo-7-fluoro-2-(methylthio)-benzoxazole + 4-[4-((2S)-2-amino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (201402-18-8) → (1,1-dimethylethyl) N-(5-bromo-7-fluoro-2-benzoxazolyl)-O-[4-oxo-4-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]butyl]-L-tyrosinate (372136-61-3)

Guidance literature:

With mercury(II) diacetate; In dichloromethane; at 100 ℃; for 4h;

upstream raw materials:

Ethyl 4-bromobutyrate

Tyr(tBu)

(2S)-2-(1-Adamantyl-methyloxycarbonylamino)-3-(4-(3-guanidinocarbonyl-propyloxy)phenyl)propionic Acid

2,2'-oxybis(2-methyl-propane)

Downstream raw materials:

(1,1-dimethylethyl) N-[[(4-bromophenyl)amino]thioxomethyl]-O-(4-ethoxy-4-oxo-butyl)-L-tyrosinate

(1,1-dimethylethyl) O-(4-ethoxy-4-oxobutyl)-N-[1-(phenylmethyl)-1H-tetrazol-5-yl]-L-tyrosinate

(1,1-dimethylethyl) N-(5-bromo-7-fluoro-2-benzoxazolyl)-O-[4-oxo-4-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]butyl]-L-tyrosinate

(1,1-dimethylethyl) N-(2-benzoxazolyl)-O-(4-ethoxy-4-oxobutyl)-L-tyrosinate

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