(S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:1410805-00-3
Molecular Formula:C₂₁H₂₈N₂O₆
Molecular Weight:404.463
Hs Code.:

Synonyms:(S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

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Chemical Property of (S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

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Technology Process of (S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

There total 3 articles about (S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1410804-99-7
(S)-methyl 3-(benzyloxy)-5-(3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidin-4-yl)isoxazole-4-carboxylate

: 1410805-00-3
(S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol302691j

Reference yield:

: 162107-48-4
tert-butyl (R)-4-ethynyl-2,2-dimethyloxazolidine-3-carboxylate

: 1410805-00-3
(S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: potassium hydrogencarbonate; N-chloro-succinimide / ethyl acetate / 72 h / 20 - 48 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C / Inert atmosphere

With N-chloro-succinimide; diisobutylaluminium hydride; potassium hydrogencarbonate; In tetrahydrofuran; hexane; ethyl acetate; toluene;
DOI:10.1021/ol302691j

Reference yield:

: 173065-22-0
(4R)-4-methoxycarbonylethynyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 1410805-00-3
(S)-tert-butyl 4-(3-(benzyloxy)-4-(hydroxymethyl)isoxazol-5-yl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogencarbonate; N-chloro-succinimide / ethyl acetate / 72 h / 20 - 48 °C / Inert atmosphere

2: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C / Inert atmosphere

With N-chloro-succinimide; diisobutylaluminium hydride; potassium hydrogencarbonate; In ethyl acetate; toluene;
DOI:10.1021/ol302691j