4-n-Octyl-β,β'-dibromostyrene

Base Information

• Chemical Name: 4-n-Octyl-β,β'-dibromostyrene
• CAS No.: 166964-89-2
• Molecular Formula: C₁₆H₂₂Br₂
• Molecular Weight: 374.159
• Mol file: 166964-89-2.mol

Synonyms:4-n-Octyl-β,β'-dibromostyrene

Chemical Property of 4-n-Octyl-β,β'-dibromostyrene

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-n-Octyl-β,β'-dibromostyrene

There total 1 articles about 4-n-Octyl-β,β'-dibromostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

carbon tetrabromide (558-13-4) + 4-octylbenzaldehyde (49763-66-8) → 4-n-Octyl-β,β'-dibromostyrene (166964-89-2)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1248/cpb.53.100

Reference yield: 84.0%

4-n-Octyl-β,β'-dibromostyrene (166964-89-2) → 1-ethynyl-4-octylbenzene (79887-13-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h;

DOI:10.1248/cpb.53.100

Reference yield:

4-n-Octyl-β,β'-dibromostyrene (166964-89-2) → fingolimod hydrochloride

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / n-butyl lithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C

2: catecholborane / tetrahydrofuran / 4 h / 80 °C

3: 157 mg / ethanol / 36 h / 20 °C

4: 90 percent / hydrogen; aq. HCl / Pd/C / ethanol / 12 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; benzo[1,3,2]dioxaborole; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; 3: Petasis reaction;

DOI:10.1248/cpb.53.100

upstream raw materials:

carbon tetrabromide

4-octylbenzaldehyde

Downstream raw materials:

1-ethynyl-4-octylbenzene

(E)-2-(4-octylphenyl)-vinylboronic acid

(E)-2-benzylamino-2-[2-(4-octylphenyl)ethenyl]propane-1,3-diol