N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide
CAS No.:1366129-21-6
Molecular Formula:C₃₃H₂₉F₂N₅O₆S
Molecular Weight:661.686
Hs Code.:

Synonyms:N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Chemical Property of N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Technology Process of N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

There total 10 articles about N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1366131-57-8
(3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(morpholino)methanone

: 1366127-99-2
N-[5-(2-amino-3-bromo-6-quinolinyl)-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

: 1366129-21-6
N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: With potassium acetate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

: 56256-14-5
4-bromo-3-methoxy-benzoic acid

: 1366129-21-6
N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate(V) / dichloromethane / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

3.1: potassium acetate; triphenylphosphine / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere; Sealed tube

With 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate(V); potassium acetate; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 2.1: Suzuki Coupling / 3.1: Suzuki Coupling;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1366129-21-6
N-[5-{2-amino-3-[2-(methyloxy)-4-(4-morpholinylcarbonyl)phenyl]-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / dichloromethane / 2 h / 20 °C

2: sulfuric acid / 2 h / 0 - 20 °C

3: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 22 h / 20 °C

4: trichlorophosphate / 1 h / 100 °C

5: triethylamine / butan-1-ol / 29 h / 135 °C / Sealed tube

6: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 60 °C / Inert atmosphere

7: trifluoroacetic acid / 6 h / 65 °C

8: potassium acetate; triphenylphosphine / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere; Sealed tube

With pyridine; N-Bromosuccinimide; sulfuric acid; potassium acetate; sodium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol; 6: Suzuki Coupling / 8: Suzuki Coupling;