(2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate

Base Information

Chemical Name:(2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate
CAS No.:119594-47-7
Molecular Formula:C₁₆H₂₃NO₅
Molecular Weight:309.362
Hs Code.:

Synonyms:(2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate

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Chemical Property of (2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate

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Technology Process of (2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate

There total 7 articles about (2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 119677-35-9
(2R,3S)-2-amino-3-hydroxy-3-phenyl-propionic acid ethyl ester

: 119594-47-7
(2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol202472z

Reference yield:

: 911475-69-9
(2S,3R)-2-amino-3-hydroxy-3-phenyl-propionic acid ethyl ester

: 119594-47-7
ethyl (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate

Guidance literature:: With di-tert-butyl dicarbonate; sodium hydrogencarbonate; In tetrahydrofuran; water; at 25 ℃; for 12h; pH=9;
DOI:10.1021/op200087f

Reference yield:

: 1072879-80-1
(2R,3R)-cis-1-(N-1-bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

: 119594-47-7
(2R,3S)-ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / acetone / 3 h / 60 °C / Inert atmosphere

2: water / acetone / 10 h / 60 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

With trifluorormethanesulfonic acid; water; sodium hydrogencarbonate; In tetrahydrofuran; acetone;
DOI:10.1021/ol202472z