(S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane

Base Information

Chemical Name:(S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane
CAS No.:1589599-06-3
Molecular Formula:C₂₂H₂₉N₃O₅S
Molecular Weight:447.555
Hs Code.:

Synonyms:(S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane

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Chemical Property of (S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane

Chemical Property:

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Technology Process of (S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane

There total 7 articles about (S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1589599-15-4
3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

: 1589599-06-3
(S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1039/c3ob42512f

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1589599-06-3
(S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 50 °C / Molecular sieve

2.1: sodium tetrahydroborate / 0 - 20 °C

3.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / 3 h / -60 °C

4.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

5.2: 24 h / 20 °C

6.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f

Reference yield:

: 145524-34-1
(S)-2-(4-methoxybenzylamino)-3-methylbutan-1-ol

: 1589599-06-3
(S)-2-isopropyl-1-(4-methoxybenzyl)-4-(2-nitrophenylsulfonyl)-1,4-diazepane

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / 3 h / -60 °C

2.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 24 h / 20 °C

4.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-imidazole; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f