3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

Base Information

Chemical Name:3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide
CAS No.:1589599-15-4
Molecular Formula:C₂₂H₃₁N₃O₆S
Molecular Weight:465.571
Hs Code.:

Synonyms:3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

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Chemical Property of 3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

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Technology Process of 3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

There total 6 articles about 3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1589598-99-1
(4S)-3-[(4-methoxyphenyl)methyl]-4-(propan-2-yl)-1,2,3-oxathiazolidine-2,2-dione

: 196214-23-0
N-(3-hydroxypropyl)-2-nitrobenzenesulfonamide

: 1589599-15-4
3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

Guidance literature:: N-(3-hydroxypropyl)-2-nitrobenzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

(4S)-3-[(4-methoxyphenyl)methyl]-4-(propan-2-yl)-1,2,3-oxathiazolidine-2,2-dione; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1039/c3ob42512f

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1589599-15-4
3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 50 °C / Molecular sieve

2.1: sodium tetrahydroborate / 0 - 20 °C

3.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / 3 h / -60 °C

4.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

5.2: 24 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f

Reference yield:

: 145524-34-1
(S)-2-(4-methoxybenzylamino)-3-methylbutan-1-ol

: 1589599-15-4
3-hydroxy-N-[(2'S)-2'-{[(4-methoxyphenyl)methyl]amino}-3-methylbutyl]-S-(2'-nitrophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / 3 h / -60 °C

2.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 24 h / 20 °C

With 1H-imidazole; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f