4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine

Base Information

Chemical Name:4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine
CAS No.:1609577-43-6
Molecular Formula:C₂₀H₁₆FN₃O₂
Molecular Weight:349.364
Hs Code.:

Synonyms:4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine

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Chemical Property of 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine

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Technology Process of 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine

There total 9 articles about 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1609577-41-4
[2-(4,6-dimethylpyrimidin-5-yl)-5-(furo[3,2-c]pyridin-4-yloxy)phenyl]methanol

: 1609577-43-6
4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 40 ℃; for 0.5h;

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1609577-43-6
4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: caesium carbonate / dimethyl sulfoxide / 16 h / 125 °C

2: N-Bromosuccinimide; tetrachloromethane; 2,2'-azobis(isobutyronitrile) / 3 h / Reflux

3: sodium acetate / N,N-dimethyl-formamide / 3 h / 80 °C

4: pyridine / tetrahydrofuran / 0.67 h / 60 °C / Microwave irradiation

5: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

7: water; sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

8: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 - 40 °C

With pyridine; tetrachloromethane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diethylamino-sulfur trifluoride; water; potassium acetate; sodium acetate; potassium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 31270-80-1
4-chlorofuro[3,2-c]pyridine

: 1609577-43-6
4-[4-(4,6-dimethylpyrimidin-5-yl)-3-(fluoromethyl)phenoxy]furo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: caesium carbonate / dimethyl sulfoxide / 16 h / 125 °C

2: N-Bromosuccinimide; tetrachloromethane; 2,2'-azobis(isobutyronitrile) / 3 h / Reflux

3: sodium acetate / N,N-dimethyl-formamide / 3 h / 80 °C

4: pyridine / tetrahydrofuran / 0.67 h / 60 °C / Microwave irradiation

5: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

7: water; sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

8: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 - 40 °C

With pyridine; tetrachloromethane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diethylamino-sulfur trifluoride; water; potassium acetate; sodium acetate; potassium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;