31270-80-1

Basic information

• Product Name: 4-CHLOROFURO[3,2-C]PYRIDINE
• Synonyms: SALOR-INT L299537-1EA;4-CHLOROFURO[3,2-C]PYRIDINE;4-CHLOROFURO[3,2-]PYRIDINE;4-Chlorofuro[3,2-c]pyridine, 95+%;1. 4-Chlorofuro[3,2-C]Pyridine;4-Chlorofuro[3,2-c]pyridine HCl;4-Chloro-5-azabenzo[b]furan, 4-Chloro-5-aza-1-benzofuran
• CAS NO: 31270-80-1
• Molecular Formula: C₇H₄ClNO
• Molecular Weight: 153.57
• EINECS: -0
• Product Categories: Heterocycles series;Halides;Fused Ring Systems
• Mol File: 31270-80-1.mol

Chemical Properties

• Melting Point: 41 °C
• Boiling Point: 243℃
• Flash Point: 101℃
• Appearance: Yellow powder
• Density: 1.377
• Vapor Pressure: 0.052mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.69±0.30(Predicted)
• CAS DataBase Reference: 4-CHLOROFURO[3,2-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROFURO[3,2-C]PYRIDINE(31270-80-1)
• EPA Substance Registry System: 4-CHLOROFURO[3,2-C]PYRIDINE(31270-80-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 31270-80-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-CHLOROFURO[3,2-C]PYRIDINE is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Antiviral, Antifungal, and Antibacterial Applications:
4-CHLOROFURO[3,2-C]PYRIDINE has been studied for its potential biological and pharmacological activities, including its use as an antiviral, antifungal, and antibacterial agent. Its ability to target and inhibit the growth of various pathogens makes it a promising candidate for the development of new treatments and preventive measures against infectious diseases.
Used in Fluorescent Probe Development:
4-CHLOROFURO[3,2-C]PYRIDINE has been investigated for its potential as a fluorescent probe for detecting biological molecules. Its fluorescent properties can be utilized to track and visualize specific biomolecules in various research and diagnostic applications, enhancing our understanding of biological processes and facilitating the development of new diagnostic tools.
Used in Organic Electronics:
4-CHLOROFURO[3,2-C]PYRIDINE has also been explored as a precursor for creating functional materials in organic electronics. Its unique chemical structure and properties make it suitable for the development of new materials with potential applications in organic light-emitting diodes (OLEDs), organic solar cells, and other electronic devices.

InChI:InChI=1/C7H4ClNO/c8-7-5-2-4-10-6(5)1-3-9-7/h1-4H

Upstream product

• 26956-43-4 5H-furo[3,2-c]pyridin-4-one 
• 57420-06-1 furo<3,2-c>pyridine N-oxide 
• 119924-26-4 (E)-3-(2-furanyl)-2-propenoyl azide 
• 98-01-1 furfural 
• 26956-43-4 furo[3,2-c]pyridine-4-ol 
• 33007-15-7 7-hydroxy-6,7-dihydro-5H-furo[3,2-c]pyridin-4-one 
• 46265-05-8 2-(2-amino-1-hydroxy-ethyl)-furan-3-carboxylic acid ethyl ester 
• 539-47-9 3-(fur-2-yl)crotonic acid 
• 20689-54-7 3-furanylacryloyl chloride 
• 29080-01-1 β-(2-Furan)-vinylisocyanat 
• 539-47-9 3-(2-furyl)acrylic acid 
• 59898-36-1 (E)-3-Furan-2-yl-acryloyl azide 

Downstream Products

• 51848-57-8 furo[3,2-c]pyridin-4-yl-(3-trifluoromethyl-phenyl)-amine 
• 46802-94-2 benzyl-furo[3,2-c]pyridin-4-yl-amine 
• 271-92-1 furo[3,2-c]pyridine 
• 81078-84-4 4-(1-piperazinyl)furo<3,2-c>pyridine 
• 86593-55-7 (4-Chloro-furo[3,2-c]pyridin-2-yl)-(4-methoxy-phenyl)-methanol 
• 86518-07-2 formyl-2 chloro-4 furo<3,2-c>pyridine 
• 86518-08-3 carboxy-2 chloro-4 furo<3,2-c>pyridine 
• 77642-49-0 2-Chlor-4-hydroxy-3-(3-phenyl-propenyl)-pyridin 
• 77642-48-9 Bis(4-furo<3,2-c>pyridinyl)-phenyl-methan 
• 86518-10-7 acetyl-2 chloro-4 furo<3,2-c>pyridine 
• 63618-60-0 methoxy-4 furo<3,2-c>pyridine 
• 76311-99-4 4-phenylfuro<3,2-c>pyridine 
• 26956-43-4 furo[3,2-c]pyridine-4-ol 
• 799293-73-5 3-bromofuro[3,2-c]pyridin-4-ylamine 

Relevant articles and documents

Organic metal compound and organic light-emitting device

Organic metal compounds and organic light-emitting devices employing the same are provided. The organic metal compound has a chemical structure of Formula (I) or Formula (II): In particular, one of the following two conditions (1) and (2) is met: (1) R1 is deuterium or C1-6 deuterated alkyl group, when R3 and R4 are independently hydrogen, halogen, C1-6 alkyl group, C1-6 fluoroalkyl or C3-12 heteroaryl group; and (2) R1 is hydrogen, deuterium, C1-6 alkyl group, C1-6 deuterated alkyl group, C3-12 heteroaryl group, or C6-12 aryl group, when at least one of R3 and R4 is C6-12 aryl group or C6-12 fluoroaryl group.

A novel furo[3,2-: C] pyridine-based iridium complex for high-performance organic light-emitting diodes with over 30% external quantum efficiency

A novel furo[3,2-c]pyridine based Ir complex, namely (pfupy)2Ir(acac), has been developed by replacing sulfur with oxygen in the C^N ligand. Compared with the thiophene-containing (pthpy)2Ir(acac), the LUMO level is elevated while the HOMO level remains almost unchanged for the resultant furan-containing (pfupy)2Ir(acac). As a consequence, the emissive maximum is blue-shifted from 556 nm of (pthpy)2Ir(acac) to 538 nm of (pfupy)2Ir(acac) together with an improved photoluminescence quantum yield of 0.80. The corresponding device based on (pfupy)2Ir(acac) realizes a record-high external quantum efficiency (EQE) of 30.5% (110.5 cd A-1) without any out-coupling technology. Even at a luminance of 1000 and 5000 cd m-2, the EQE still remains at 26.6% (96.4 cd A-1) and 25.6% (92.7 cd A-1), respectively, indicative of the gentle efficiency roll-off. The results clearly demonstrate the great potential of furan-based functional materials applied in OLEDs.

Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists

A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.

TRICYCLIC COMPOUND AND MEDICAL USE THEREOF

The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa to Xe are each a carbon atom or a nitrogen atom, m is 0 to 2, and ring A to ring C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

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Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

AZABENZOFURAN SUBSTITUTED THIOUREAS; INHIBITORS OF VIRAL REPLICATION

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Furopyridines. XXIII [1]. Synthesis and Reactions of Chloropyridine Derivatives of Furo[2,3-b]-, -[2,3-c]- and -[3,2-c]pyridine

Chlorination of the N-oxides of furo[2,3-b]- 1a, -[2,3-c]- 1b and -[3,2-c]pyridine 1c with phosphorus oxychloride afforded compounds substituted normally at the α- or γ-position to the ring nitrogen, 2a, 2′a, 2b, 2c, 2′c and 2″c, and in addition, in the case of 1b, compounds substituted on the furan ring, 2′b and 2″b. The structures of these compounds were confirmed from their ir, nmr and mass spectra. The major chlorinated products 2a, 2b and 2c were converted to methoxy- 5a, 5b and 5c, N-pyrrolidyl- 7a, 7b and 7c, and phenylthiofuropyridines 8a, 8b, and 8c.

The Thienopyridine and Furopyridine Rings: New Pharmacophores with Potential Antipsychotic Activity

Two new arylpiperazine derivatives, the 4-(1-piperazinyl)thieno- and -furopyridine ring systems, have been synthesized and appended via tetramethylene chains to various imide rings.Target compounds from each series were found to have significant activity in the blockade of apomorphine stereotypy and apomorphine-induced climbing, the Sidman avoidance response, and the conditioned avoidance response.In addition, while potent affinity for serotonin 5-HT1 and 5-HT2 receptors was observed for both the thieno- and furopyridine derivatives,the interaction of these molecules with the dopamine D2 receptor was weak.Electrophysiological studies of the lead prototypes from each series, involving compounds 22 and 33, indicate these two molecules have distinctively different effects on dopamine neurons in areas A9 and A10.Despite the similarity these molecules share in their behavioral indices of antipsychotic acivity, it is likely that the thieno- and furopyridine rings employ different mechanisms to achieve this convergence of biological effects.