(S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

Base Information

Chemical Name:(S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester
CAS No.:306775-52-0
Molecular Formula:C₃₀H₂₈Cl₂N₂O₆
Molecular Weight:583.468
Hs Code.:

(S)-N<sup>α</sup>-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

Synonyms:(S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

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Chemical Property of (S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

Chemical Property:

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Technology Process of (S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

There total 4 articles about (S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 27532-96-3
glycine tert-butyl ester hydrochloride

: 306775-51-9
(S)-N^α-phthaloyl-O-(2,6-dichlorobenzyl)tyrosine

: 306775-52-0
(S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/jo000530d

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 306775-52-0
(S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / CuSO₄*5H₂O; NaOH / H₂O; methanol / 5 h / 20 °C

2: 62 percent / Et₃N / dioxane; H₂O / Heating

3: 100 percent / BOP; HOBT; DIPEA / CH₂Cl₂ / 5 h / 20 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; copper(II) sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; 1: Etherification / 2: cyclocondensation / 3: Condensation;
DOI:10.1021/jo000530d

Reference yield:

: 40298-69-9
4-(2,6-dichlorobenzyloxy)-L-phenylalanine

: 306775-52-0
(S)-N^α-phthaloyl-O-2,6-dichlorobenzyltyrosinylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / Et₃N / dioxane; H₂O / Heating

2: 100 percent / BOP; HOBT; DIPEA / CH₂Cl₂ / 5 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; 1: cyclocondensation / 2: Condensation;
DOI:10.1021/jo000530d