(E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide

Base Information

Chemical Name:(E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide
CAS No.:1397293-14-9
Molecular Formula:C₂₀H₂₃ClN₄O₃
Molecular Weight:402.881
Hs Code.:

Synonyms:(E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide

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Technology Process of (E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide

There total 3 articles about (E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1245750-25-7
C₁₉H₂₀ClN₃O₃

: 593-56-6
N-methoxylamine hydrochloride

: 1397293-14-9
(E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide

Guidance literature:: With pyridine; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm3007917

Reference yield:

: 1397293-17-2
3-acetyl-α,α-dimethylbenzyl isocyanate

: 1397293-14-9
(E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 6 h / 70 °C / Inert atmosphere

2: pyridine / 2 h / 90 °C / Inert atmosphere

With pyridine; In tetrahydrofuran;
DOI:10.1021/jm3007917

Reference yield:

: 2094-99-7
1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl)benzene

: 1397293-14-9
(E)-2-chloro-5-(3-(2-(3-(1-(methoxyimino)ethyl)phenyl)propan-2-yl)ureido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ozone; oxygen / dichloromethane / -78 °C

1.2: 10 h / 20 °C

2.1: tetrahydrofuran / 6 h / 70 °C / Inert atmosphere

3.1: pyridine / 2 h / 90 °C / Inert atmosphere

With pyridine; oxygen; ozone; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm3007917