tert-butyloxycarbonyl-sarcosyl-tyrosine amide

Base Information

• Chemical Name: tert-butyloxycarbonyl-sarcosyl-tyrosine amide
• CAS No.: 80621-91-6
• Molecular Formula: C₁₇H₂₅N₃O₅
• Molecular Weight: 351.403
• Mol file: 80621-91-6.mol

Synonyms:tert-butyloxycarbonyl-sarcosyl-tyrosine amide

Chemical Property of tert-butyloxycarbonyl-sarcosyl-tyrosine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyloxycarbonyl-sarcosyl-tyrosine amide

There total 4 articles about tert-butyloxycarbonyl-sarcosyl-tyrosine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyloxycarbonyl-sarcosyl-tyrosine methyl ester (1150315-17-5) → tert-butyloxycarbonyl-sarcosyl-tyrosine amide (80621-91-6)

Guidance literature:

With ammonia; In methanol; at 0 - 20 ℃; for 48h;

Reference yield:

N-(tert-butoxycarbonyl)sarcosine (13734-36-6) + (S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride (53559-18-5,117888-79-6,117888-80-9,2442565-30-0) → tert-butyloxycarbonyl-sarcosyl-tyrosine amide (80621-91-6)

Guidance literature:

N-(tert-butoxycarbonyl)sarcosine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

(S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/psc.1379

Reference yield:

N-(tert-butoxycarbonyl)sarcosine (13734-36-6) → tert-butyloxycarbonyl-sarcosyl-tyrosine amide (80621-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 13.17 h / 0 - 20 °C

2: ammonia / methanol / 48 h / 0 - 20 °C

With ammonia; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

N-(tert-butoxycarbonyl)sarcosine

L-tyrosine methyl ester HCl

tert-butyloxycarbonyl-sarcosyl-tyrosine methyl ester

(S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride

Downstream raw materials:

sarcosyl-tyrosine amide trifluoracetate

creatinyl-tyrosine amide

Refernces

• 1、 Burov, Sergey,Leko, Maria,Dorosh, Marina,Dobrodumov, Anatoliy,Veselkina, Olga. "Creatinyl amino acids-new hybrid compounds with neuroprotective activity". experimental part. p. 620 - 626. Retrieved 2012/04/04.