((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

Base Information

Chemical Name:((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate
CAS No.:1343407-81-7
Molecular Formula:C₄₇H₅₆N₄O₁₄
Molecular Weight:900.98
Hs Code.:

((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

Synonyms:((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

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Chemical Property of ((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

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Technology Process of ((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

There total 17 articles about ((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1343407-80-6
((2S,2’S,E)-1,1’-(4,4’-(propane-1,3-diylbis(oxy))bis(2-amino-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene)diacetate

: 2937-50-0
Allyl chloroformate

: 1343407-82-8
((S)-1-(4-(3-(4-((S)-2-(acetoxymethyl)-4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-1-carbonyl)-5-(((allyloxy)carbonyl)amino)-2-methoxyphenoxy)propoxy)-2-amino-5-methoxybenzoyl)-4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrol-2-yl)methyl acetate

: 1343407-81-7
((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

Guidance literature:: With pyridine; In dichloromethane; at -78 ℃; for 2h;

Reference yield:

: 1201630-40-1
1,1‘-[[(propane-1,3-diyl)dioxy]bis[(5-methoxy-2-nitro-1,4-phenylene)carbonyl]]bis[(2S,4R)-methyl-4-hydroxypyrrolidine-2-carboxylate]

: 1343407-81-7
((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

Guidance literature:: Multi-step reaction with 7 steps

1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 °C

2: 2,6-dimethylpyridine / dichloromethane / 1 h / -45 - 40 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / 32 °C / Inert atmosphere

4: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C

6: zinc; formic acid / ethyl acetate; ethanol / 0.5 h / 15 - 33 °C

7: pyridine / dichloromethane / 2 h / -78 °C

With pyridine; 2,6-dimethylpyridine; lithium borohydride; formic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; sodium carbonate; triethylamine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene; 3: Suzuki Coupling;

Reference yield:

: C₁₉H₁₆Cl₂N₂O₁₀

: 1343407-81-7
((2S,2'S,E)-1,1'-(4,4'-(propane-1,3-diylbis(oxy))bis(2-(((allyloxy)carbonyl)amino)-5-methoxybenzoyl))bis(4-((E)-prop-1-en-1-yl)-2,3-dihydro-1H-pyrrole-2,1-diyl))bis(methylene) diacetate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 0.42 h / -40 °C

2: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 °C

3: 2,6-dimethylpyridine / dichloromethane / 1 h / -45 - 40 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / 32 °C / Inert atmosphere

5: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 - 20 °C

7: zinc; formic acid / ethyl acetate; ethanol / 0.5 h / 15 - 33 °C

8: pyridine / dichloromethane / 2 h / -78 °C

With pyridine; 2,6-dimethylpyridine; lithium borohydride; formic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; sodium carbonate; triethylamine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene; 4: Suzuki Coupling;