Technology Process of 7-N-acetyldemethyllavendamycin β-hydroxyethyl ester dibenzyl phosphate
There total 5 articles about 7-N-acetyldemethyllavendamycin β-hydroxyethyl ester dibenzyl phosphate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 20 ℃;
for 4 - 4.2h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 87 percent / HCOONH4 / Pd/C / dimethylformamide / 4.5 h / 20 °C
2: 94 percent / methoxybenzene; dimethylformamide / 5.5 h / 95 - 160 °C
3: 142 mg / Ph3P; diethyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C
With
ammonium formate; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; methoxybenzene; N,N-dimethyl-formamide;
2: Pictet-Spengler condensation / 3: Mitsunobu reaction;
DOI:10.1021/jm0304414
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / Et3N / dibutyl ether / 5 h / Heating
2: 87 percent / HCOONH4 / Pd/C / dimethylformamide / 4.5 h / 20 °C
3: 94 percent / methoxybenzene; dimethylformamide / 5.5 h / 95 - 160 °C
4: 142 mg / Ph3P; diethyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C
With
ammonium formate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; dibutyl ether; methoxybenzene; N,N-dimethyl-formamide;
3: Pictet-Spengler condensation / 4: Mitsunobu reaction;
DOI:10.1021/jm0304414
