Multi-step reaction with 8 steps
1.1: potassium carbonate / acetonitrile / 1 h / Reflux
2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C
3.1: hydrogenchloride; zinc / tetrahydrofuran; water / 20 °C
3.2: pH 9
4.1: acetic acid / 1 h / 50 °C
5.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 60 °C
5.2: pH ~ 3 - 4
6.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C
7.1: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C
8.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C
With
hydrogenchloride; boron dimethyl-trifluoro sulphide; water; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; zinc;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;