1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]

Base Information

Chemical Name:1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]
CAS No.:1355089-62-1
Molecular Formula:C₂₆H₂₆FNO₂
Molecular Weight:403.496
Hs Code.:

Synonyms:1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]

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Chemical Property of 1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]

Chemical Property:

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Technology Process of 1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]

There total 5 articles about 1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1355089-61-0
1-benzyl-4-[3-(benzyloxy)-6-bromo-2-fluorophenoxymethyl]-1,2,3,6-tetrahydropyridine

: 1355089-62-1
1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 175 ℃; for 1h; Microwave irradiation;

Reference yield:

: 586-95-8
pyridine-4-methanol

: 1355089-62-1
1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 20 °C

1.2: 100 °C

2.1: acetone / 40 °C

3.1: sodium tetrahydroborate; methanol / 4 h / -10 - 20 °C

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 1 h / 175 °C / Microwave irradiation

With methanol; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In 1-methyl-pyrrolidin-2-one; acetone; mineral oil; benzene;

Reference yield:

: 941294-52-6
1-(benzyloxy)-4-bromo-2,3-difluorobenzene

: 1355089-62-1
1'-benzyl-6-(benzyloxy)-7-fluoro-2H-spiro[1-benzofuran-3,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 20 °C

1.2: 100 °C

2.1: acetone / 40 °C

3.1: sodium tetrahydroborate; methanol / 4 h / -10 - 20 °C

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 1 h / 175 °C / Microwave irradiation

With methanol; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In 1-methyl-pyrrolidin-2-one; acetone; mineral oil; benzene;