1-(Benzyloxy)-4-bromo-2,3-difluorobenzene

Base Information

• Chemical Name: 1-(Benzyloxy)-4-bromo-2,3-difluorobenzene
• CAS No.: 941294-52-6
• Molecular Formula: C13H9BrF2O
• Molecular Weight: 299.115
• Hs Code.: 2909309090
• Mol file: 941294-52-6.mol

Synonyms:1-Bromo-4-(benzyloxy)-2,3-difluorobenzene;Benzyl 4-bromo-2,3-difluorophenyl ether, 4-(Benzyloxy)-2,3-difluorobromobenzene;1-(Benzyloxy)-4-bromo-2,3-difluorobenzene98%

Chemical Property of 1-(Benzyloxy)-4-bromo-2,3-difluorobenzene

Chemical Property:

• Vapor Pressure: 0.000234mmHg at 25°C
• Boiling Point: 335.4°C at 760 mmHg
• Flash Point: 188.6°C
• PSA: 9.23000
• Density: 1.505g/cm³
• LogP: 4.30630
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(Benzyloxy)-4-bromo-2,3-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Benzyloxy)-4-bromo-2,3-difluorobenzene

There total 2 articles about 1-(Benzyloxy)-4-bromo-2,3-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

2,3-difluoro-4-bromophenol (144292-32-0) + benzyl bromide (100-39-0) → 1-(benzyloxy)-4-bromo-2,3-difluorobenzene (941294-52-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 4h; Inert atmosphere;

Reference yield:

2,3-difluorophenol (6418-38-8) → 1-(benzyloxy)-4-bromo-2,3-difluorobenzene (941294-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; trifluoroacetic acid / 20 °C

2: potassium carbonate / acetonitrile / 20 °C

With bromine; potassium carbonate; trifluoroacetic acid; In acetonitrile;

DOI:10.1139/V10-143

Reference yield: 83.0%

pyridine-4-methanol (586-95-8) + 1-(benzyloxy)-4-bromo-2,3-difluorobenzene (941294-52-6) → 4-[3-(benzyloxy)-6-bromo-2-fluorophenoxymethyl]pyridine (1355089-59-6)

Guidance literature:

pyridine-4-methanol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20 ℃; for 0.5h;

1-(benzyloxy)-4-bromo-2,3-difluorobenzene; In 1-methyl-pyrrolidin-2-one; mineral oil; at 100 ℃;

upstream raw materials:

2,3-difluoro-4-bromophenol

benzyl bromide

2,3-difluorophenol

Downstream raw materials:

1-{2,3-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

C₁₅H₁₁BrF₂O₂

C₂₄H₂₇F₂NO₆

C₂HF₃O₂*C₁₂H₁₃F₂NO₄

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