2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one

Base Information

Chemical Name:2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one
CAS No.:1417917-48-6
Molecular Formula:C₂₇H₃₀N₄O₄
Molecular Weight:474.56
Hs Code.:

Synonyms:2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one

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Chemical Property of 2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one

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Technology Process of 2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one

There total 8 articles about 2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38768-08-0
2-(tosyloxy)tropone

: 2-{(R)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine hydrochloride

: 1417917-48-6
2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one

: 1417917-49-7
C₂₇H₃₀N₄O₄

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; for 16h;

Reference yield:

: 38768-08-0
2-(tosyloxy)tropone

: 2-{(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetamidine hydrochloride

: 1417917-48-6
2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one

: 1417917-49-7
C₂₇H₃₀N₄O₄

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; for 16h;

Reference yield:

: 370864-67-8
4-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1417917-48-6
2-{(R)-3-[4-(4-Methoxy-3-methyl-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one

: 1417917-49-7
C₂₇H₃₀N₄O₄

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 13 h / 85 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 - 20 °C / Inert atmosphere

5.1: sodium methylate / methanol / 3 h / 40 °C

5.2: 2 h / 40 °C

6.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 16 h

With tetrabutylammomium bromide; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;