N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide
CAS No.:1374227-37-8
Molecular Formula:C₁₉H₂₃N₇O₅S
Molecular Weight:461.502
Hs Code.:

Synonyms:N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

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Chemical Property of N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

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Technology Process of N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

There total 3 articles about N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

: 1374227-30-1
N-(2-(4-amino-6-chloro-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

: 24313-88-0
3,4,5-Trimethoxyaniline

: 1374227-37-8
N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100 ℃; for 0.166667h; Inert atmosphere; Sealed vessel; Microwave irradiation;
DOI:10.1016/j.tet.2012.03.041

Reference yield:

: C₁₀H₉Cl₂N₅O₂S

: 1374227-37-8
N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / tetrahydrofuran; water / 1 h / -15 - 20 °C

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 0.17 h / 100 °C / Inert atmosphere; Sealed vessel; Microwave irradiation

With ammonia; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; water; 2: Buchwald amination;
DOI:10.1016/j.tet.2012.03.041

Reference yield:

: 37073-18-0
N-(2-aminophenyl)methanesulfonamide

: 1374227-37-8
N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -15 °C

2: ammonia / tetrahydrofuran; water / 1 h / -15 - 20 °C

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 0.17 h / 100 °C / Inert atmosphere; Sealed vessel; Microwave irradiation

With ammonia; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; 3: Buchwald amination;
DOI:10.1016/j.tet.2012.03.041