37073-18-0

Basic information

• Product Name: N-(2-aminophenyl)methanesulfonamide
• Synonyms: N-(2-aminophenyl)methanesulfonamide;2-(Methylsulfonamido)aniline;N-(2-aminophenyl)methanesulfonamide(SALTDATA: FREE);2'-Aminomethanesulfonanilide;2-(Methanesulfonamido)aniline;N-(2-Aminophenyl)
• CAS NO: 37073-18-0
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 186.23
• Product Categories: Amines and Anilines
• Mol File: 37073-18-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 340.1 °C at 760 mmHg
• Flash Point: 159.5 °C
• Appearance: /
• Density: 1.408 g/cm³
• Vapor Pressure: 8.78E-05mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-(2-aminophenyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-aminophenyl)methanesulfonamide(37073-18-0)
• EPA Substance Registry System: N-(2-aminophenyl)methanesulfonamide(37073-18-0)

Safety Data

• Hazardous Substances Data: 37073-18-0(Hazardous Substances Data)

Usage

General Description

N-(2-aminophenyl)methanesulfonamide, also known as AMSA, is a chemical compound with the formula C7H10N2O2S. It is a sulfonamide derivative and a member of the benzene sulfonamides class of compounds. AMSA is commonly used as an antineoplastic agent and is being investigated for its potential as a cancer treatment. It works by inhibiting the activity of the enzyme topoisomerase II, which is involved in DNA replication and repair. This inhibition ultimately leads to the disruption of DNA synthesis and cell division, resulting in the suppression of tumor growth. AMSA has also been studied for its anti-inflammatory and antiviral properties, making it a versatile and valuable compound in the field of pharmaceutical research.

InChI:InChI=1/C7H10N2O2S/c1-12(10,11)9-7-5-3-2-4-6(7)8/h2-5,9H,8H2,1H3

Upstream product

• 88-74-4 2-nitro-aniline 
• 85150-03-4 N-(2-nitrophenyl)methanesulfonamide 
• 124-63-0 methanesulfonyl chloride 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 1187344-38-2 N-(2-(2-chloro-5-nitropyrimidin-4-ylamino)phenyl)methanesulfonamide 
• 1374227-37-8 N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide 
• 1374227-30-1 N-(2-(4-amino-6-chloro-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide 
• 199105-19-6 1-(2-methanesulfonylamidophenyl)piperazine 
• 1579960-78-3 N-(2-(4-(3-(2-(4-bromophenoxy)ethoxy)-2-hydroxypropyl)piperazin-1-yl)phenyl)methanoesulfonamide 
• 25024-96-8 C₁₁H₁₇N₃O₂S*ClH 
• 1448791-18-1 N-(2-(4-chloro-6-(2,4-dimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methylsulfonamide 

Relevant articles and documents

Discovery and characterization of an acridine radical photoreductant

Photoinduced electron transfer (PET) is a phenomenon whereby the absorption of light by a chemical species provides an energetic driving force for an electron-transfer reaction1–4. This mechanism is relevant in many areas of chemistry, including the study of natural and artificial photosynthesis, photovoltaics and photosensitive materials. In recent years, research in the area of photoredox catalysis has enabled the use of PET for the catalytic generation of both neutral and charged organic free-radical species. These technologies have enabled previously inaccessible chemical transformations and have been widely used in both academic and industrial settings. Such reactions are often catalysed by visible-light-absorbing organic molecules or transition-metal complexes of ruthenium, iridium, chromium or copper5,6. Although various closed-shell organic molecules have been shown to behave as competent electron-transfer catalysts in photoredox reactions, there are only limited reports of PET reactions involving neutral organic radicals as excited-state donors or acceptors. This is unsurprising because the lifetimes of doublet excited states of neutral organic radicals are typically several orders of magnitude shorter than the singlet lifetimes of known transition-metal photoredox catalysts7–11. Here we document the discovery, characterization and reactivity of a neutral acridine radical with a maximum excited-state oxidation potential of ?3.36 volts versus a saturated calomel electrode, which is similarly reducing to elemental lithium, making this radical one of the most potent chemical reductants reported12. Spectroscopic, computational and chemical studies indicate that the formation of a twisted intramolecular charge-transfer species enables the population of higher-energy doublet excited states, leading to the observed potent photoreducing behaviour. We demonstrate that this catalytically generated PET catalyst facilitates several chemical reactions that typically require alkali metal reductants and can be used in other organic transformations that require dissolving metal reductants.

Amide type organic nitrogen ligand compound and synthesis method thereof

The invention is claimed to protect an N-(2-(bis(2-hydroxyl-2-methyl propyl)amido)phenyl) amide type organic nitrogen ligand compound and a preparing method thereof. The method is simple and feasibleand is supplementation and development in the field of o

PYRROLOPYRIMIDINES AS FAK AND ALK INHIBITERS FOR TREATMENT OF CANCERS AND OTHER DISEASES

Disclosed are compounds which inhibit the activity of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK), compositions containing the compounds, and methods of treating diseases during which FAK and ALK are expressed. The diseases are, for example, cancers.