37073-18-0

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-aminophenyl)methanesulfonamide is used as an antineoplastic agent for its ability to inhibit topoisomerase II, thereby disrupting DNA synthesis and cell division, which is instrumental in the suppression of tumor growth.
Used in Cancer Treatment:
AMSA is utilized as a potential cancer treatment, particularly for its role in targeting and inhibiting the activity of the enzyme topoisomerase II, which is essential for DNA replication and repair. This action results in the prevention of tumor growth and the promotion of cancer cell death.
Used in Research and Development:
N-(2-aminophenyl)methanesulfonamide is also used in pharmaceutical research and development for its anti-inflammatory and antiviral properties, expanding its potential applications beyond cancer treatment to include other therapeutic areas.

InChI:InChI=1/C7H10N2O2S/c1-12(10,11)9-7-5-3-2-4-6(7)8/h2-5,9H,8H2,1H3

Upstream product

• 88-74-4 2-nitro-aniline 
• 85150-03-4 N-(2-nitrophenyl)methanesulfonamide 
• 124-63-0 methanesulfonyl chloride 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 199105-19-6 1-(2-methanesulfonylamidophenyl)piperazine 
• 1579960-78-3 N-(2-(4-(3-(2-(4-bromophenoxy)ethoxy)-2-hydroxypropyl)piperazin-1-yl)phenyl)methanoesulfonamide 
• 1374227-30-1 N-(2-(4-amino-6-chloro-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide 
• 25024-96-8 C₁₁H₁₇N₃O₂S*ClH 
• 1448791-18-1 N-(2-(4-chloro-6-(2,4-dimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methylsulfonamide 
• 1448791-08-9 N-(2-(4-chloro-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methylsulfonamide 
• 1448791-46-5 N-(2-(4-(methylamino)-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methylsulfonamide 

Relevant academic research and scientific papers

Discovery and characterization of an acridine radical photoreductant

Photoinduced electron transfer (PET) is a phenomenon whereby the absorption of light by a chemical species provides an energetic driving force for an electron-transfer reaction1–4. This mechanism is relevant in many areas of chemistry, including the study of natural and artificial photosynthesis, photovoltaics and photosensitive materials. In recent years, research in the area of photoredox catalysis has enabled the use of PET for the catalytic generation of both neutral and charged organic free-radical species. These technologies have enabled previously inaccessible chemical transformations and have been widely used in both academic and industrial settings. Such reactions are often catalysed by visible-light-absorbing organic molecules or transition-metal complexes of ruthenium, iridium, chromium or copper5,6. Although various closed-shell organic molecules have been shown to behave as competent electron-transfer catalysts in photoredox reactions, there are only limited reports of PET reactions involving neutral organic radicals as excited-state donors or acceptors. This is unsurprising because the lifetimes of doublet excited states of neutral organic radicals are typically several orders of magnitude shorter than the singlet lifetimes of known transition-metal photoredox catalysts7–11. Here we document the discovery, characterization and reactivity of a neutral acridine radical with a maximum excited-state oxidation potential of ?3.36 volts versus a saturated calomel electrode, which is similarly reducing to elemental lithium, making this radical one of the most potent chemical reductants reported12. Spectroscopic, computational and chemical studies indicate that the formation of a twisted intramolecular charge-transfer species enables the population of higher-energy doublet excited states, leading to the observed potent photoreducing behaviour. We demonstrate that this catalytically generated PET catalyst facilitates several chemical reactions that typically require alkali metal reductants and can be used in other organic transformations that require dissolving metal reductants.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Amide type organic nitrogen ligand compound and synthesis method thereof

The invention is claimed to protect an N-(2-(bis(2-hydroxyl-2-methyl propyl)amido)phenyl) amide type organic nitrogen ligand compound and a preparing method thereof. The method is simple and feasibleand is supplementation and development in the field of o

Heteroaromatic compound and application thereof to drug

The invention discloses a heteroaromatic compound and application thereof to drug. In particular, the invention provides a heteroaromatic compound or stereoisomers thereof, geometric isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, and a pharmaceutical composition comprising the compound provided by the invention. The invention also discloses application of the compound provided by the invention or the pharmaceutical composition thereofto preparation of a medicine for reatment of autoimmune diseases or proliferative diseases.

PYRROLOPYRIMIDINES AS FAK AND ALK INHIBITERS FOR TREATMENT OF CANCERS AND OTHER DISEASES

Disclosed are compounds which inhibit the activity of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK), compositions containing the compounds, and methods of treating diseases during which FAK and ALK are expressed. The diseases are, for example, cancers.

Palladium-catalyzed intramolecular sulfonamidation/oxidation of imines: Access to multifunctional benzimidazoles

O-Sulfonamidophenylimines undergo intramolecular sulfonamidation/oxidation to produce 1,2-disubstituted benzimidazoles upon treatment with palladium(II) chloride/(diacetoxyiodo)benzene and potassium carbonate at room temperature. The substituent scope at

Highly enantioselective aldol reactions using N-arylprolinamides with enhanced acidity and double H-bonding potential

We have designed and synthesized N-arylprolinamides 7-10 with a potential to involve in the binding of electrophilic aldehydes via two N-H?O hydrogen bonds for application in organocatalytic aldol reactions. The catalyst 10 is shown to afford aldol produc

SULFONAMIDES AS ZAP-70 INHIBITORS

The invention relates to compounds of formula (I), wherein R1 to R9 and R4a have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of

FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.