<1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle

Base Information

• Chemical Name: <1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle
• CAS No.: 146036-91-1
• Molecular Formula: C₁₉H₃₁N₂O₆P
• Molecular Weight: 414.439
• Mol file: 146036-91-1.mol

Synonyms:<1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle

Chemical Property of <1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle

There total 2 articles about <1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

L-N-Boc-Ala (15761-38-3) + diethyl 1-aminophenylmethylphosphonate (16814-08-7,42077-95-2,42077-97-4) → <1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle (146036-91-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; for 0.75h; Ambient temperature;

DOI:10.1016/S0040-4020(01)92278-1

Reference yield:

(1-Isocyanato-1-phenyl)methylphosphonate de diethyle (74732-28-8) → <1-(tert-Butyloxycarbonyl-L-alanyl-amino)-1-phenyl>methylphosphonate de diethyle (146036-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) 12 N HCl, 2) K₂CO₃ / 1) Et₂O, reflux, 30 min, 2) H₂O

2: 89 percent / BOP, NEt₃ / CH₂Cl₂ / 0.75 h / Ambient temperature

With hydrogenchloride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)92278-1

upstream raw materials:

L-N-Boc-Ala

diethyl 1-aminophenylmethylphosphonate

(1-Isocyanato-1-phenyl)methylphosphonate de diethyle