[(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester
• CAS No.: 135911-86-3
• Molecular Formula: C₄₀H₄₅N₅O₅
• Molecular Weight: 675.828
• Mol file: 135911-86-3.mol

Synonyms:[(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Chemical Property of [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

There total 5 articles about [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) → [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester (135911-86-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide / 18 h / Ambient temperature

2: triethylamine / 1,2-dimethoxy-ethane / 18 h / Ambient temperature

3: HCl (gas) / ethyl acetate / 0.33 h / -25 °C

4: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 20 h / Ambient temperature

5: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 20 h / Ambient temperature

With hydrogenchloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00113a025

Reference yield:

[(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentyl]-carbamic acid tert-butyl ester → [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester (135911-86-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 20h; Yield given; Ambient temperature;

DOI:10.1021/jm00113a025

Reference yield:

(S)-2-Amino-N-(1H-benzoimidazol-2-ylmethyl)-2-phenyl-acetamide → [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester (135911-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 20 h / Ambient temperature

2: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 20 h / Ambient temperature

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00113a025

upstream raw materials:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

Boc-Phg-OSu