2-METHYL-5-TRIFLUOROMETHOXYBENZIMIDAZOLE

Base Information

• Chemical Name: 2-METHYL-5-TRIFLUOROMETHOXYBENZIMIDAZOLE
• CAS No.: 114164-97-5
• Molecular Formula: C9H7 F3 N2 O
• Molecular Weight: 216.16
• Hs Code.: 2933990090
• Mol file: 114164-97-5.mol

Synonyms:Benzimidazole,2-methyl-5(or 6)-(trifluoromethoxy)- (6CI)

Chemical Property of 2-METHYL-5-TRIFLUOROMETHOXYBENZIMIDAZOLE

Chemical Property:

• PSA: 37.91000
• LogP: 2.76990
• Storage Temp.: Room temperature.

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-5-(trifluoromethoxy)benzoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-5-TRIFLUOROMETHOXYBENZIMIDAZOLE

There total 2 articles about 2-METHYL-5-TRIFLUOROMETHOXYBENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

→ 2-methyl-5-trifluoromethoxybenzimidazole (114164-97-5)

Guidance literature:

Reference yield: 44.0%

4-(trifluoromethoxy)benzene-1,2-diamine (658-89-9) + acetic anhydride (108-24-7) → 2-methyl-5-trifluoromethoxybenzimidazole (114164-97-5)

Guidance literature:

4-(trifluoromethoxy)benzene-1,2-diamine; acetic anhydride; at 20 ℃;

With hydrogenchloride; for 7h; Reflux;

With ammonium hydroxide; In water;

Reference yield:

4-trifluoromethylphenylamine (455-14-1) + 2-methyl-5-trifluoromethoxybenzimidazole (114164-97-5) + 2,6-dichloropyrazine (4774-14-5) → 6-[2-methyl-5-(trifluoromethoxy)-1H-benzimidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine + 6-[2-methyl-6-(trifluoromethoxy)-1H-benzimidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine

Guidance literature:

2-methyl-5-trifluoromethoxybenzimidazole; 2,6-dichloropyrazine; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃; for 1.5h;

4-trifluoromethylphenylamine; With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,2-dimethoxyethane; at 95 - 100 ℃; for 89h; Inert atmosphere;

upstream raw materials:

4-(trifluoromethoxy)benzene-1,2-diamine

acetic anhydride

Refernces

• 1、 -. "SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE". Page/Page column 30. . Retrieved 2010/01/29.