(4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

Base Information

Chemical Name:(4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone
CAS No.:1396778-37-2
Molecular Formula:C₂₅H₂₅F₂N₃O₂
Molecular Weight:437.489
Hs Code.:

Synonyms:(4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

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Chemical Property of (4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

Chemical Property:

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Technology Process of (4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

There total 6 articles about (4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1396779-82-0
(4-(3-amino-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

: 100-52-7
benzaldehyde

: 1396778-37-2
(4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 7693-52-9
4-bromo-2-nitrophenol

: 1396778-37-2
(4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

2: caesium carbonate / tol-BINAP; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; dimethyl sulfoxide / 14 h / 90 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; methanol / 3 h / 20 °C

4: potassium hydroxide / acetonitrile; water / 0.5 h / -78 - 20 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 4 h

6: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tol-BINAP; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1396779-79-5
(4-(4-hydroxy-3-nitrophenyl)piperazin-1-yl)(phenyl)methanone

: 1396778-37-2
(4-(3-(benzyl amino)-4-(difluoromethoxy)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / acetonitrile; water / 0.5 h / -78 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 4 h

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C / Inert atmosphere

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; potassium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane; water; acetonitrile;