(S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester

Base Information

• Chemical Name: (S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester
• CAS No.: 79256-86-3
• Molecular Formula: C₁₃H₂₂NO₃PS
• Molecular Weight: 303.362

Synonyms:(S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester

Chemical Property of (S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester

Chemical Property:

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Technology Process of (S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester

There total 1 articles about (S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4S,5R)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione (1089310-25-7) + methyl iodide (74-88-4) → (S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester (79256-86-3)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 1.) dioxan, overnight, 2.) methanol, 0.5 h;

DOI:10.1039/P19810002368

Reference yield: 95.0%

(S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester (79256-86-3) → (2R,4S,5R)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-one (79236-67-2)

Guidance literature:

With silver nitrate; triethylamine; In acetonitrile; for 0.25h;

DOI:10.1039/P19810002368

Reference yield: 92.0%

acetic anhydride (108-24-7) + (S)-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-thiophosphoramidic acid O-ethyl ester S-methyl ester (79256-86-3) → Acetic acid (1R,2S)-2-[((S)-ethoxy-methylsulfanyl-phosphoryl)-methyl-amino]-1-phenyl-propyl ester (79236-65-0)

Guidance literature:

With pyridine;

DOI:10.1039/P19810002368

upstream raw materials:

(2S,4S,5R)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione

methyl iodide

Downstream raw materials:

Acetic acid (1R,2S)-2-[((S)-ethoxy-methylsulfanyl-phosphoryl)-methyl-amino]-1-phenyl-propyl ester

(2S,4S,5R)-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

(2R,4S,5R)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-one

(R)-Thiophosphoric acid O-ethyl ester S-methyl ester O'-((1R,2S)-2-methylamino-1-phenyl-propyl) ester; hydrochloride

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