1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

Base Information

Chemical Name:1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one
CAS No.:1598417-04-9
Molecular Formula:C₂₃H₂₆BrN₅O₄
Molecular Weight:516.395
Hs Code.:

Synonyms:1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

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Chemical Property of 1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

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Technology Process of 1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

There total 9 articles about 1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 163596-75-6
4-bromo-3-nitrobenzaldehyde

: 1-[2-(4-amino-piperidin-1-yl)-ethyl]-7-methoxy-1H-quinoxalin-2-one hydrochloride

: 1598417-04-9
1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

Guidance literature:: 4-bromo-3-nitrobenzaldehyde; 1-[2-(4-amino-piperidin-1-yl)-ethyl]-7-methoxy-1H-quinoxalin-2-one hydrochloride; With titanium(IV) isopropylate; In ethanol; at 0 - 20 ℃;

With sodium tetrahydroborate; acetic acid; In ethanol; at 20 ℃; for 3h;

Reference yield:

: 55687-29-1
7-methoxy-3,4-dihydroquinoxalin-2(1H)-one

: 1598417-04-9
1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; sodium hydroxide / 4 h / 80 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 0 - 20 °C

4.1: titanium(IV) isopropylate / ethanol / 0 - 20 °C

4.2: 3 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; dihydrogen peroxide; sodium hydride; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 558443-53-1
[1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

: 1598417-04-9
1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 0 - 20 °C

4.1: titanium(IV) isopropylate / ethanol / 0 - 20 °C

4.2: 3 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; sodium hydride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;