558443-53-1

Basic information

• Product Name: Carbamic acid, [1-(2-hydroxyethyl)-4-piperidinyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [1-(2-hydroxyethyl)-4-piperidinyl]-, 1,1-dimethylethyl ester (9CI);1-(2-HYDROXYETHYL)-4-PIPERIDINYL]-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER;tert-butyl N-[1-(2-hydroxyethyl)piperidin-4-yl]carbamate
• CAS NO: 558443-53-1
• Molecular Formula: C₁₂H₂₄N₂O₃
• Molecular Weight: 244.33056
• Product Categories: N-BOC;PIPERIDINE
• Mol File: 558443-53-1.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 376.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• PKA: 12.33±0.20(Predicted)
• CAS DataBase Reference: Carbamic acid, [1-(2-hydroxyethyl)-4-piperidinyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-(2-hydroxyethyl)-4-piperidinyl]-, 1,1-dimethylethyl ester (9CI)(558443-53-1)
• EPA Substance Registry System: Carbamic acid, [1-(2-hydroxyethyl)-4-piperidinyl]-, 1,1-dimethylethyl ester (9CI)(558443-53-1)

Safety Data

• Hazardous Substances Data: 558443-53-1(Hazardous Substances Data)

Usage

General Description

Carbamic acid, [1-(2-hydroxyethyl)-4-piperidinyl]-, 1,1-dimethylethyl ester (9CI), also known as tiropramide, is a chemical compound with the molecular formula C13H26N2O3. It is an ester of carbamic acid and is commonly used as a medication for the treatment of gastrointestinal disorders such as functional dyspepsia and irritable bowel syndrome. Tiropramide is a smooth muscle relaxant and anticholinergic agent, which means it works by blocking the action of acetylcholine in the body, leading to a decrease in muscle contractions in the gastrointestinal tract. It is available in oral dosage forms and is used to relieve symptoms such as abdominal pain, bloating, and discomfort associated with gastrointestinal conditions. Tiropramide should be used under the supervision of a healthcare professional, and its use may be associated with certain side effects and drug interactions.

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 540-51-2 2-bromoethanol 

Downstream Products

• 89850-72-6 4-amino-1-(2-hydroxyethyl)piperidine 
• 1393381-46-8 N-(2-(4-aminopiperidin-1-yl)ethyl)-4-((9-chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzamide 
• 1393381-45-7 tert-butyl (1-(2-(4-((9-chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzamido)ethyl)piperidin-4-yl)carbamate 
• 1236222-70-0 {1-[2-(4-benzyloxy-6-methoxy-[1,5]naphthyridin-3-yloxy)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester 
• 1598417-05-0 7-methoxy-1-(2-(4-(3-methyl-4-nitrobenzylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one 
• 1598417-04-9 1-(2-(4-(4-bromo-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one 
• 1598417-01-6 1-(2-(7-methoxyquinoxalin-2-yloxy)ethyl)-N-(4-methyl-3-nitrobenzyl)piperidin-4-amine 
• 1598417-00-5 7-methoxy-1-(2-(4-(4-methyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one 
• 1598416-94-4 1-(2-(4-(4-fluoro-3-nitrobenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one 

Relevant articles and documents

2, 3-dihydrobenzofuranamide derivatives and application thereof

The invention discloses 2,3-dihydrobenzofuranamide derivatives and an application thereof, and particularly relates to novel 2,3-dihydrobenzofuranamide derivatives and a pharmaceutical composition containing the compounds. The compounds can be used as a 5-HT4 receptor agonist. The invention also relates to methods for preparing the compounds and the pharmaceutical composition, and an application of the compounds and the pharmaceutical composition in the preparation of drugs for treating diseases related to the activity of the 5-HT4 receptor, especially constipation type allergic bowel syndrome(IBS-C).

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS

Compounds of formula (I) that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

NOVEL COMPOUND HAVING ANGIOGENESIS INHIBITORY ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Disclosed are an anti-angiogenic compound, represented by Chemical Formula I, or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutically acceptable composition including the same. Because the compound of Chemical Formular I potently suppresses the angiogenesis, the compound of Chemical Formula I is applicable to the prevention and treatment of diseases caused by aberrant activity of vascular endothelial growth factor, and available as an anti-angiogenic agent.