(1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

Base Information

Chemical Name:(1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol
CAS No.:90056-25-0
Molecular Formula:C₁₆H₂₂OSe
Molecular Weight:309.31
Hs Code.:

Synonyms:(1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

Suppliers and Price of (1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

There total 2 articles about (1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: 76339-71-4
(2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanone

: 90129-51-4
(1R,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

: 90056-25-0
(1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.0833333h;
DOI:10.1248/cpb.39.2514

Reference yield:

: 1666-13-3
diphenyl diselenide

: 90056-25-0
(1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaBH₄, acetic acid / 1) EtOH, 0 deg C, 1 h, 2) EtOH, 3 h

2: 78.5 percent / LiAlH₄ / diethyl ether / 0.08 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; acetic acid; In diethyl ether;
DOI:10.1248/cpb.39.2514

Reference yield:

: 90056-25-0
(1S,2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanol

: 138945-23-0
(2R)-3-<(tert-butyldimethylsilyl)oxymethyl>-2-<2-(methoxycarbonyl)-2-phenylselenopropyl>-4-methyl-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 13 steps

1: 1.02 g / pyridinium p-toluenesulfonate / CH₂Cl₂ / 7 h / Ambient temperature

2: 1) borane-THF complex, 2) 35percent H₂O₂, 3N KOH / 1) THF, -65 deg C, 2) 65 deg C, 15 h

3: 60 percent / ethyl acetate / 3 h / -65 °C

4: 30 percent / 10percent H₂SO₄ / acetone / 72 h / 50 °C

5: 70 percent / W₂-Raney nickel / acetone / 7 h / Ambient temperature

6: 89 percent / Jones reagent / acetone / 0.08 h / 0 °C

7: 1) lithium diisopropylamide (from diisopropylamine and n-butyllithium hexane solution at 0 deg C) / 1) THF, -78 deg C, 1 h, 2) -78 deg C, 2 h

8: 1a) O₃, NaHCO₃, 1b) methylsulfide / 1a) aq. CH₂Cl₂, MeOH, -78 deg C, 30 min, 1b) r.t., 1 h, 2) ether

9: 1) piperidine, molecular sieves 3 Angstroem / 1) benzene, r.t., 26 h, 2) THF, -110 deg C, 1 h

10: 28 percent / 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 0.33 h / -78 °C

11: 1) 0.5 M 9-borabicyclo<3.3.1>nonane, 2) 2 N NaOH, 35percent H₂O₂ / 1) THF, r.t., 2 h, 2) 3h

12: 97 percent / imidazole / tetrahydrofuran / 10 h / Ambient temperature

13: 1) lithium diisopropylamide (from diisopropylamine and n-butyllithium hexane solution at -78 deg C), 2) hexamethylphophoric triamide / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 20 min

With piperidine; 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; jones reagent; borane-THF; methylthiol; 3 A molecular sieve; sulfuric acid; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ozone; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; W₂-Raney Nickel; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone;
DOI:10.1248/cpb.39.2514