[[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

Base Information

Chemical Name:[[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea
CAS No.:1423167-89-8
Molecular Formula:C₂₃H₁₅ClF₃N₅O₃
Molecular Weight:501.852
Hs Code.:

Synonyms:[[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

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Chemical Property of [[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

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Technology Process of [[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

There total 8 articles about [[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1423022-47-2
2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-benzoic acid

: 1423167-88-7
2-amino-5-[(E)-(carbamoylhydrazono)methyl]-3-methylbenzoic acid

: 1423167-89-8
[[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

Guidance literature:: 2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-benzoic acid; With methanesulfonyl chloride; triethylamine; In acetonitrile; at 0 ℃; for 0.5h;

2-amino-5-[(E)-(carbamoylhydrazono)methyl]-3-methylbenzoic acid; In acetonitrile; at 0 - 25 ℃;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1423167-89-8
[[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 3 h / 20 - 30 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C

2.2: 2 h / 0 - 25 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 20 h / Reflux

4.1: lithium hydroxide / tetrahydrofuran; water / 20 - 25 °C

5.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 °C

5.2: 0 - 25 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; triethylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

Reference yield:

: 444993-18-4
2-(prop-2-yloxycarbonyl)-5-trfluoromethylphenylboronic acid

: 1423167-89-8
[[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 20 h / Reflux

2.1: lithium hydroxide / tetrahydrofuran; water / 20 - 25 °C

3.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 °C

3.2: 0 - 25 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;