5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide

Base Information

Chemical Name:5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide
CAS No.:1424088-97-0
Molecular Formula:C₂₄H₂₀ClF₃N₆O₃
Molecular Weight:532.909
Hs Code.:

Synonyms:5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide

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Chemical Property of 5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide

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Technology Process of 5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide

There total 9 articles about 5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1423167-89-8
[[2-[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)phenyl]-8-methyl-4-oxo-3,1-benzoxazin-6-yl]methyleneamino]urea

: 74-89-5
methylamine

: 1424088-97-0
5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide

Guidance literature:: In tetrahydrofuran; at 20 - 25 ℃; for 3h;

Reference yield:

: 4389-45-1
3-methylantranilic acid

: 1424088-97-0
5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 75 °C

2.1: triethylsilane; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 5 h / 80 °C

3.1: acetic acid / ethanol / 2 h / 70 °C

4.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 °C

4.2: 0 - 25 °C

5.1: tetrahydrofuran / 3 h / 20 - 25 °C

With triethylsilane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sodium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 444993-17-3
4-trifluoromethyl-benzoic acid isopropyl ester

: 1424088-97-0
5-[(E)-(carbamoylhydrazono)methyl]-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C

1.2: 2 h / 0 - 25 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 20 h / Reflux

3.1: lithium hydroxide / tetrahydrofuran; water / 20 - 25 °C

4.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 °C

4.2: 0 - 25 °C

5.1: tetrahydrofuran / 3 h / 20 - 25 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; triethylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;