(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid

Base Information

Chemical Name:(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid
CAS No.:1259967-11-7
Molecular Formula:C₂₇H₂₁F₄NO₅
Molecular Weight:515.461
Hs Code.:

Synonyms:(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid

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Chemical Property of (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid

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Technology Process of (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid

There total 3 articles about (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₁F₄NO₃

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1259967-11-7
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid

Guidance literature:: With sodium carbonate; In water; acetonitrile; at 20 ℃; for 2.5h;
DOI:10.1021/ol102610q

Reference yield:

: 1259967-10-6
(S)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)-2-(tert-butoxycarbonylamino)propanoic acid

: 1259967-11-7
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; trifluoroacetic acid / water / 1 h / 20 °C

2: sodium carbonate / water; acetonitrile / 2.5 h / 20 °C

With triethylsilane; sodium carbonate; trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/ol102610q

Reference yield:

: 136207-26-6,34702-60-8
(S)-2-((tert-butoxycarbonyl)amino)-3-(perfluorophenyl)propanoic acid

: 1259967-11-7
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(allyloxy)-2,3,5,6-tetrafluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium / 6 h / 0 - 90 °C / Inert atmosphere

2: triethylsilane; trifluoroacetic acid / water / 1 h / 20 °C

3: sodium carbonate / water; acetonitrile / 2.5 h / 20 °C

With triethylsilane; sodium; sodium carbonate; trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/ol102610q