(4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine

Base Information

• Chemical Name: (4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine
• CAS No.: 1001057-14-2
• Molecular Formula: C₂₀H₁₉BrClN₃
• Molecular Weight: 416.748
• Mol file: 1001057-14-2.mol

Synonyms:(4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine

Chemical Property of (4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine

Chemical Property:

Purity/Quality:

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Technology Process of (4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine

There total 1 articles about (4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromo-3-(pyrrolidin-1-ylmethyl)phenylamine + 4,7-dichloroquinoline (86-98-6,1138471-54-1) → (4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine (1001057-14-2)

Guidance literature:

With hydrogenchloride; In acetonitrile; Heating;

DOI:10.1016/j.tet.2007.08.115

Reference yield: 99.0%

(4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine (1001057-14-2) + 4-fluoroboronic acid (1765-93-1) → (7-chloroquinolin-4-yl)(4'-fluoro-2-(pyrrolidin-1-ylmethyl)biphenyl-4-yl)amine

Guidance literature:

With tetrabutylammomium bromide; sodium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In ethanol; toluene; at 60 ℃; for 48h;

DOI:10.1016/j.tet.2007.08.115

Reference yield:

(4-bromo-3-(pyrrolidin-1-yl)methylphenyl)(7-chloroquinolin-4-yl)amine (1001057-14-2) + 4-acetylphenylboronic acid (149104-90-5) → 1-[4'-(7-chloroquinolin-4-ylamino)-2'-(pyrrolidin-1-ylmethyl)biphenyl-4-yl]ethanone

Guidance literature:

With tetrabutylammomium bromide; sodium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In ethanol; toluene; at 60 ℃; for 24h;

DOI:10.1016/j.tet.2007.08.115

upstream raw materials:

4,7-dichloroquinoline