DT-ME PHOSPHONAMIDITE

Base Information

• Chemical Name: DT-ME PHOSPHONAMIDITE
• CAS No.: 114079-04-8
• Molecular Formula: C₃₈H₄₈N₃O₇P
• Molecular Weight: 689.789
• Mol file: 114079-04-8.mol

Synonyms:5'-Dimethoxytrityl-2'-deoxythymidine3'-methyl(N,N-diisopropyl)phosphoamidite

Chemical Property of DT-ME PHOSPHONAMIDITE

Chemical Property:

• PKA: 9.55±0.10(Predicted)
• PSA: 117.84000
• LogP: 6.60410

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DT-ME PHOSPHONAMIDITE

There total 9 articles about DT-ME PHOSPHONAMIDITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite (114079-04-8,129446-26-0,129446-28-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.333333h; Ambient temperature;

DOI:10.1016/S0040-4039(00)95529-1

Reference yield: 85.0%

N,N,N',N'-Tetraisopropyl-P-methylphosphonous diamide (110838-39-6) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite (114079-04-8,129446-26-0,129446-28-2)

Guidance literature:

With 2,4,6-trimethyl-pyridine; hydrogenchloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0040-4039(00)74210-9

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → 5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite (114079-04-8,129446-26-0,129446-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent

2: 85 percent / 2,4,6-collidine, HCl / CH₂Cl₂ / 24 h / 20 °C

With 2,4,6-trimethyl-pyridine; hydrogenchloride; In dichloromethane;

DOI:10.1016/S0040-4039(00)74210-9

upstream raw materials:

1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

N,N,N',N'-Tetraisopropyl-P-methylphosphonous diamide

5'-O-(4-4'-dimethoxytrityl)thymidine

N,N-diisopropyl-O-p-nitrophenyl-P-methylphosponoamidite

Downstream raw materials:

C₆₃H₆₅N₄O₁₄P

C₆₃H₆₀N₇O₁₃P

(MeO)2TrdTp(Me)T

5'-O-dimethoxytritylthymidine-3'-O-β-cyanoethoxymethylphosphonite