3-O-Methyl-6-fluoro-L-Dopa, OMFD

Base Information

Chemical Name:3-O-Methyl-6-fluoro-L-Dopa, OMFD
CAS No.:114077-01-9
Molecular Formula:C₁₀H₁₂FNO₄
Molecular Weight:229.208
Hs Code.:
Mol file:114077-01-9.mol

Synonyms:3-O-Methyl-6-fluoro-L-Dopa, OMFD;L-Tyrosine, 2-fluoro-5-methoxy-;O-Methyl-6-fluorodopa;OMFD

Suppliers and Price of 3-O-Methyl-6-fluoro-L-Dopa, OMFD

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-O-Methyl-6-fluoro-L-Dopa, OMFD

Chemical Property:

Boiling Point:422.5±45.0 °C(Predicted)
PKA:2.24±0.25(Predicted)
PSA：0.00000
Density:1.396±0.06 g/cm3(Predicted)
LogP:0.00000

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-O-Methyl-6-fluoro-L-Dopa, OMFD

There total 17 articles about 3-O-Methyl-6-fluoro-L-Dopa, OMFD which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Amino-3-(4-benzyloxy-2-fluoro-5-methoxy-phenyl)-propionic acid

: 141554-67-8,114077-01-9
3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 6h; under 1034.3 Torr; Yield given; Ambient temperature;

Reference yield:

: 100-39-0
benzyl bromide

: 141554-67-8,114077-01-9
3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine

Guidance literature:: Multi-step reaction with 6 steps

1: 42 percent / K₂CO₃ / acetone / 24 h / Ambient temperature

2: 89 percent / K₂CO₃ / acetone / 16 h / Heating

3: 78.8 percent / NaOAc, HOAc / 2 h / 95 °C

4: 40percent NaOH / ethanol; H₂O / 0.17 h / Heating

5: 62.8 percent / H₂ / 10percent Pd-C / methanol / 6 h / 2068.6 - 2327.2 Torr

6: 3N HCl / 24 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; sodium acetate; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; ethanol; water; acetone;
DOI:10.1016/S0022-1139(00)82354-4

Reference yield:

: 79418-72-7
4-Benzyloxy-2-fluoro-5-methoxybenzaldehyde

: 141554-67-8,114077-01-9
3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine

Guidance literature:: Multi-step reaction with 4 steps

1: 78.8 percent / NaOAc, HOAc / 2 h / 95 °C

2: 40percent NaOH / ethanol; H₂O / 0.17 h / Heating

3: 62.8 percent / H₂ / 10percent Pd-C / methanol / 6 h / 2068.6 - 2327.2 Torr

4: 3N HCl / 24 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; In methanol; ethanol; water;
DOI:10.1016/S0022-1139(00)82354-4